CJC-1295 + Ipamorelin Research Stack: GHRH-Analog and Ghrelin-Mimetic Pharmacology

TL;DR. CJC-1295 is a GHRH-analog (30-residue) with a Drug Affinity Complex (DAC) modification that extends half-life to ~6-8 days. Ipamorelin is a 5-residue pentapeptide ghrelin-mimetic (GHS-R1a agonist) with a very short half-life (~2 h) and clean selectivity. When co-administered in research protocols, the two produce synergistic pulsatile GH-axis response through complementary receptors.

Receptor pharmacology

The pharmacology is complementary: CJC-1295 raises baseline GH-pulse amplitude via prolonged GHRH signalling; Ipamorelin fires additional pulses via ghrelin-receptor stimulation without collateral hormone release. In published research protocols, the two are typically administered concurrently to model amplitude-plus-frequency GH-axis responses that neither achieves alone.

Storage and reconstitution

Both are supplied as lyophilised powder. Standard reconstitution:

• CJC-1295 (2 mg vial): 1-2 mL bacteriostatic water → 1-2 mg/mL working stock. Stable 30 days at 2-8 °C reconstituted.
• Ipamorelin (5 mg vial): 1-2 mL bacteriostatic water → 2.5-5 mg/mL. Stable 30 days at 2-8 °C reconstituted; 24 months lyophilised at -20 °C.

Use a reconstitution calculator to translate a published mg/kg dose into your syringe-unit volume in seconds.

CoA requirements

For institutional research on either peptide, insist on batch-level CoAs carrying HPLC ≥99%, MS identity confirmation, Karl-Fischer water content, HPIEC acetate, and LAL endotoxin. CJC-1295's DAC modification adds a maleimidopropionyl linker to Lys30, verify the modification is present on the MS trace.

Bulk sourcing considerations

Both peptides are widely available at institutional volumes in 2026. Points to verify with a bulk supplier:

• Batch consistency: request 3 back-to-back CoAs at your target volume. Purity spread should be < 0.5%.
• DAC vs non-DAC: some vendors sell "CJC-1295" as the non-DAC variant (Modified GRF 1-29) with a 30-min half-life. Confirm which you're buying, they're pharmacologically distinct.
• Lead time: standard 24-48 h handling + regional transit (2-5 days intra-EU, 5-7 global).

Working with Penlab Peptide

Penlab supplies both CJC-1295 (with DAC) and Ipamorelin research-grade in 2, 5, and 10 mg vial formats, with batch-level CoAs from third-party accredited labs. Verified institutional buyers ordering above €50,000/month qualify for tiered bulk discounts (20-50% off list). Visit the bulk procurement portal or email sales@penlabpeptide.com.

Products are sold strictly for in-vitro laboratory research (Research Use Only) by KYC-verified institutional buyers.